Focused ultrasound-mediated small-molecule delivery to potentiate immune checkpoint blockade in solid tumors

Focused ultrasound-mediated small-molecule delivery to potentiate immune checkpoint blockade in solid tumors

In the last decade, immune checkpoint blockade (ICB) has revolutionized the standard of treatment for solid tumors. Despite success in several immunogenic tumor types evidenced by improved survival, ICB remains largely unresponsive, especially in “cold tumors” with poor lymphocyte infiltration. In a...

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Bibliographic Details
Main Authors: Qiuyu Wu, Yuanhang Xia, Xiaohe Xiong, Xinxing Duan, Xiaoxiao Pang, Fugui Zhang, Song Tang, Junlei Su, Shuqiong Wen, Li Mei, Richard D. Cannon, Ping Ji, Zhanpeng Ou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
focused ultrasound
small-molecule delivery systems
microbubbles
nanoparticles
immune checkpoint blockade
solid tumors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1169608/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1169608/full

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