The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients
BackgroundSerum 1,5-anhydro-D-glucitol (1,5-AG) is a novel biomarker for short-term glycemic status and postprandial hyperglycemia. The association between serum 1,5-AG levels and coronary artery calcification (CAC) through a quantitative assessment using optical coherence tomography (OCT) is unclea...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.997649/full |
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| author | Hsin-I Teng Hsin-I Teng Hsin-I Teng Hsiang-Yao Chen Hsiang-Yao Chen Hsiang-Yao Chen Chuan-Tsai Tsai Chuan-Tsai Tsai Chuan-Tsai Tsai Wei-Chieh Huang Wei-Chieh Huang Wei-Chieh Huang Ying-Ying Chen Ying-Ying Chen Chien-Hung Hsueh William K. Hau Tse-Min Lu Tse-Min Lu Tse-Min Lu Tse-Min Lu |
| author_facet | Hsin-I Teng Hsin-I Teng Hsin-I Teng Hsiang-Yao Chen Hsiang-Yao Chen Hsiang-Yao Chen Chuan-Tsai Tsai Chuan-Tsai Tsai Chuan-Tsai Tsai Wei-Chieh Huang Wei-Chieh Huang Wei-Chieh Huang Ying-Ying Chen Ying-Ying Chen Chien-Hung Hsueh William K. Hau Tse-Min Lu Tse-Min Lu Tse-Min Lu Tse-Min Lu |
| author_sort | Hsin-I Teng |
| collection | DOAJ |
| description | BackgroundSerum 1,5-anhydro-D-glucitol (1,5-AG) is a novel biomarker for short-term glycemic status and postprandial hyperglycemia. The association between serum 1,5-AG levels and coronary artery calcification (CAC) through a quantitative assessment using optical coherence tomography (OCT) is unclear. We aimed to evaluate this association using OCT in patients with diabetes mellitus (DM).MethodsFrom June 2016 to December 2019, we prospectively enrolled 256 patients who underwent OCT-guided percutaneous coronary intervention (PCI). Half of the patients had diabetes. Patients were followed up for a mean period of 1.8 ± 0.8 years (median: 2.2 years). The relative calcium index and relative lipid core index measured by quantitative OCT analysis were used to evaluate the intra-plaque calcium and lipid levels of culprit plaques. We also analyzed the correlation between serum 1,5-AG levels and long-term major adverse cardiovascular events.ResultsSerum 1,5-AG levels were significantly lower in diabetic patients than in non-diabetic patients (DM vs. non-DM: 55.6 ± 27.9 μg/mL vs. 63.7 ± 26.1 μg/mL, p = 0.016), and lower in fibrocalcified lesions than in fibrotic or fibrolipidic lesions (fibrocalcified vs. fibrotic or fibrolipidic: 42.8 ± 19.1 vs. 72.9 ± 25.2 or 66.4 ± 27.5 μg/mL, p < 0.001, respectively). In addition, we found a significant inverse correlation between serum 1,5-AG levels and relative calcium index (r = −0.729, p < 0.001). In multivariate Cox regression analysis, low serum 1,5-AG level was identified as an independent predictor for major adverse cardiovascular events in diabetic patients (p = 0.043), but not in non-diabetic patients (p = 0.748) after adjusting for age and sex.ConclusionThis study revealed that low serum 1,5-AG levels were associated with an increased risk of CAC as assessed by OCT, especially in diabetic patients. Low serum 1,5-AG levels may predict future major adverse cardiovascular events in diabetic patients undergoing OCT-guided PCI. |
| first_indexed | 2024-04-11T09:43:59Z |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T09:43:59Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-44ed63043c4444039ee716cb94cea5f02022-12-22T04:31:07ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.997649997649The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patientsHsin-I Teng0Hsin-I Teng1Hsin-I Teng2Hsiang-Yao Chen3Hsiang-Yao Chen4Hsiang-Yao Chen5Chuan-Tsai Tsai6Chuan-Tsai Tsai7Chuan-Tsai Tsai8Wei-Chieh Huang9Wei-Chieh Huang10Wei-Chieh Huang11Ying-Ying Chen12Ying-Ying Chen13Chien-Hung Hsueh14William K. Hau15Tse-Min Lu16Tse-Min Lu17Tse-Min Lu18Tse-Min Lu19Heart Center, Cheng Hsin General Hospital, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDepartment of Internal Medicine, Taipei Hospital, Ministry of Health and Welfare, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaDepartment of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanTaiVeCoron Study Group, Taipei Veterans General Hospital Coronary Intervention Study Group, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, TaiwanDepartment of Health Care Center, Taipei Veterans General Hospital, Taipei, TaiwanBackgroundSerum 1,5-anhydro-D-glucitol (1,5-AG) is a novel biomarker for short-term glycemic status and postprandial hyperglycemia. The association between serum 1,5-AG levels and coronary artery calcification (CAC) through a quantitative assessment using optical coherence tomography (OCT) is unclear. We aimed to evaluate this association using OCT in patients with diabetes mellitus (DM).MethodsFrom June 2016 to December 2019, we prospectively enrolled 256 patients who underwent OCT-guided percutaneous coronary intervention (PCI). Half of the patients had diabetes. Patients were followed up for a mean period of 1.8 ± 0.8 years (median: 2.2 years). The relative calcium index and relative lipid core index measured by quantitative OCT analysis were used to evaluate the intra-plaque calcium and lipid levels of culprit plaques. We also analyzed the correlation between serum 1,5-AG levels and long-term major adverse cardiovascular events.ResultsSerum 1,5-AG levels were significantly lower in diabetic patients than in non-diabetic patients (DM vs. non-DM: 55.6 ± 27.9 μg/mL vs. 63.7 ± 26.1 μg/mL, p = 0.016), and lower in fibrocalcified lesions than in fibrotic or fibrolipidic lesions (fibrocalcified vs. fibrotic or fibrolipidic: 42.8 ± 19.1 vs. 72.9 ± 25.2 or 66.4 ± 27.5 μg/mL, p < 0.001, respectively). In addition, we found a significant inverse correlation between serum 1,5-AG levels and relative calcium index (r = −0.729, p < 0.001). In multivariate Cox regression analysis, low serum 1,5-AG level was identified as an independent predictor for major adverse cardiovascular events in diabetic patients (p = 0.043), but not in non-diabetic patients (p = 0.748) after adjusting for age and sex.ConclusionThis study revealed that low serum 1,5-AG levels were associated with an increased risk of CAC as assessed by OCT, especially in diabetic patients. Low serum 1,5-AG levels may predict future major adverse cardiovascular events in diabetic patients undergoing OCT-guided PCI.https://www.frontiersin.org/articles/10.3389/fcvm.2022.997649/full15-anhydro-D-glucitolcoronary artery calcificationoptical coherence tomographydiabetes mellitus1,5-AG |
| spellingShingle | Hsin-I Teng Hsin-I Teng Hsin-I Teng Hsiang-Yao Chen Hsiang-Yao Chen Hsiang-Yao Chen Chuan-Tsai Tsai Chuan-Tsai Tsai Chuan-Tsai Tsai Wei-Chieh Huang Wei-Chieh Huang Wei-Chieh Huang Ying-Ying Chen Ying-Ying Chen Chien-Hung Hsueh William K. Hau Tse-Min Lu Tse-Min Lu Tse-Min Lu Tse-Min Lu The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients Frontiers in Cardiovascular Medicine 1 5-anhydro-D-glucitol coronary artery calcification optical coherence tomography diabetes mellitus 1,5-AG |
| title | The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| title_full | The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| title_fullStr | The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| title_full_unstemmed | The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| title_short | The clinical impact of serum 1,5-anhydro-D-glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| title_sort | clinical impact of serum 1 5 anhydro d glucitol levels on coronary artery calcification and adverse outcomes assessed by coronary optical coherence tomography in diabetic patients |
| topic | 1 5-anhydro-D-glucitol coronary artery calcification optical coherence tomography diabetes mellitus 1,5-AG |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.997649/full |
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