Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.

Bibliographic Details
Main Authors: Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34864-8

Internet

https://doi.org/10.1038/s41467-022-34864-8

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