Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas
LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.
Bibliographic Details
| Main Authors: |
Joseph G. Kern,
Andrew M. Tilston-Lunel,
Anthony Federico,
Boting Ning,
Amy Mueller,
Grace B. Peppler,
Eleni Stampouloglou,
Nan Cheng,
Randy L. Johnson,
Marc E. Lenburg,
Jennifer E. Beane,
Stefano Monti,
Xaralabos Varelas |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34864-8
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