Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas
LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34864-8 |
| _version_ | 1811207540446330880 |
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| author | Joseph G. Kern Andrew M. Tilston-Lunel Anthony Federico Boting Ning Amy Mueller Grace B. Peppler Eleni Stampouloglou Nan Cheng Randy L. Johnson Marc E. Lenburg Jennifer E. Beane Stefano Monti Xaralabos Varelas |
| author_facet | Joseph G. Kern Andrew M. Tilston-Lunel Anthony Federico Boting Ning Amy Mueller Grace B. Peppler Eleni Stampouloglou Nan Cheng Randy L. Johnson Marc E. Lenburg Jennifer E. Beane Stefano Monti Xaralabos Varelas |
| author_sort | Joseph G. Kern |
| collection | DOAJ |
| description | LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas. |
| first_indexed | 2024-04-12T04:06:19Z |
| format | Article |
| id | doaj.art-44ef2e9ad3d946d1af1096e43d649666 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T04:06:19Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-44ef2e9ad3d946d1af1096e43d6496662022-12-22T03:48:36ZengNature PortfolioNature Communications2041-17232022-11-0113111310.1038/s41467-022-34864-8Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomasJoseph G. Kern0Andrew M. Tilston-Lunel1Anthony Federico2Boting Ning3Amy Mueller4Grace B. Peppler5Eleni Stampouloglou6Nan Cheng7Randy L. Johnson8Marc E. Lenburg9Jennifer E. Beane10Stefano Monti11Xaralabos Varelas12Department of Biochemistry, Boston University School of MedicineDepartment of Biochemistry, Boston University School of MedicineDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Biochemistry, Boston University School of MedicineDepartment of Biochemistry, Boston University School of MedicineDepartment of Biochemistry, Boston University School of MedicineDepartment of Cancer Biology, University of Texas, MD Anderson Cancer CenterDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Medicine, Computational Biomedicine Section, Boston University School of MedicineDepartment of Biochemistry, Boston University School of MedicineLATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.https://doi.org/10.1038/s41467-022-34864-8 |
| spellingShingle | Joseph G. Kern Andrew M. Tilston-Lunel Anthony Federico Boting Ning Amy Mueller Grace B. Peppler Eleni Stampouloglou Nan Cheng Randy L. Johnson Marc E. Lenburg Jennifer E. Beane Stefano Monti Xaralabos Varelas Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas Nature Communications |
| title | Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas |
| title_full | Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas |
| title_fullStr | Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas |
| title_full_unstemmed | Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas |
| title_short | Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas |
| title_sort | inactivation of lats1 2 drives luminal basal plasticity to initiate basal like mammary carcinomas |
| url | https://doi.org/10.1038/s41467-022-34864-8 |
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