JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication

JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication

Background & Aims: HBV infection is a global health burden. Covalently closed circular DNA (cccDNA) transcriptional regulation is a major cause of poor cure rates of chronic hepatitis B (CHB) infection. Herein, we evaluated whether targeting host factors to achieve functional silencing of cc...

Full description

Bibliographic Details
Main Authors: Xu Kong, Zuofeng Liu, Ruyi Zhang, Fu’an Xie, Rubing Liang, Yong Zhang, Lingling Yu, Wensheng Yang, Xi Li, Qiang Chen, Bei Li, Yilin Hong, Ming Li, Xiaogang Xia, Lingwei Gu, Lijuan Fu, Xiaohua Li, Ye Shen, Ting Wu, Chundong Yu, Wengang Li
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:JHEP Reports
Subjects:
Chronic hepatitis B
HBV replication
cccDNA transcription
JMJD2D
HBx
Intervention target
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923001805

Internet

http://www.sciencedirect.com/science/article/pii/S2589555923001805

Similar Items