Oridonin Synergistically Enhances the Pro-Apoptotic Effect of Venetoclax on Acute Myeloid Leukemia Cells by Inhibiting AKT Signaling

Oridonin Synergistically Enhances the Pro-Apoptotic Effect of Venetoclax on Acute Myeloid Leukemia Cells by Inhibiting AKT Signaling

Background: Acute myeloid leukemia (AML) is a recurrence-prone hematologic malignancy. The advent of molecularly targeted therapies provides new opportunities to enhance the effectiveness of AML treatments. Venetoclax, a selective inhibitor of the anti-apoptotic protein Bcl-2, has shown promising re...

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Bibliographic Details
Main Authors: Lin Chen, Dongbei Li, Xiaoli Guo, Cheng Cheng, Xudong Wei
Format: Article
Language:English
Published: IMR Press 2023-09-01
Series:Frontiers in Bioscience-Landmark
Subjects:
oridonin
venetoclax
akt signaling pathway
acute myeloid leukemia (aml)
apoptosis
Online Access:https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809195

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https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809195

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