Receptor for Advanced Glycation End-Products Promotes Activation of Alveolar Macrophages through the NLRP3 Inflammasome/TXNIP Axis in Acute Lung Injury

Receptor for Advanced Glycation End-Products Promotes Activation of Alveolar Macrophages through the NLRP3 Inflammasome/TXNIP Axis in Acute Lung Injury

The roles of thioredoxin-interacting protein (TXNIP) and receptor for advanced glycation end-products (RAGE)-dependent mechanisms of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-driven macrophage activation during acute lung injury are underinvestigated. Cultured THP-1 ma...

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Bibliographic Details
Main Authors: Woodys Lenga Ma Bonda, Marianne Fournet, Ruoyang Zhai, Jean Lutz, Raiko Blondonnet, Céline Bourgne, Charlotte Leclaire, Cécile Saint-Béat, Camille Theilliere, Corinne Belville, Damien Bouvier, Loïc Blanchon, Marc Berger, Vincent Sapin, Matthieu Jabaudon
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
acute respiratory distress syndrome
acute lung injury
macrophage activation
alveolar inflammation
receptor for advanced glycation end-products
thioredoxin-interacting protein
Online Access:https://www.mdpi.com/1422-0067/23/19/11659

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https://www.mdpi.com/1422-0067/23/19/11659

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