Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti-Toxoplasma Immunity

Inflammasome Activation Dampens Type I IFN Signaling to Strengthen Anti-Toxoplasma Immunity

ABSTRACT Innate immunity acts as the first line of defense against pathogen invasion. During Toxoplasma gondii infection, multiple innate immune sensors are activated by invading microbes or pathogen-associated molecular patterns (PAMPs). However, how inflammasome is activated and its regulatory mec...

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Bibliographic Details
Main Authors: Zhiqiang Hu, Dan Wu, Jiansen Lu, Yufen Zhang, Shao-Meng Yu, Yingchao Xie, Hongyu Li, Jianwu Yang, De-Hua Lai, Ke Zeng, Huaji Jiang, Zhao-Rong Lun, Xiao Yu
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
toxoplasmosis
inflammasome
type I interferon
SOCS1
Online Access:https://journals.asm.org/doi/10.1128/mbio.02361-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02361-22

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