PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small ne...

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Bibliographic Details
Main Authors: Xiuxiang Tan, Jan Bednarsch, Mika Rosin, Simone Appinger, Dong Liu, Georg Wiltberger, Juan Garcia Vallejo, Sven Arke Lang, Zoltan Czigany, Shiva Boroojerdi, Nadine T. Gaisa, Peter Boor, Roman David Bülow, Judith De Vos-Geelen, Liselot Valkenburg-van Iersel, Marian C. Clahsen-van Groningen, Evelien J. M. de Jong, Bas Groot Koerkamp, Michail Doukas, Flavio G. Rocha, Tom Luedde, Uwe Klinge, Shivan Sivakumar, Ulf Peter Neumann, Lara Rosaline Heij
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
cholangiocarcinoma
liver cancer
tumor microenvironment
nerve fiber density
immune checkpoint
immune cells
Online Access:https://www.mdpi.com/2072-6694/14/9/2190

Internet

https://www.mdpi.com/2072-6694/14/9/2190

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