Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts. Here, we an...

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Bibliografiska uppgifter
Huvudupphovsmän: Lauren LeBon, Tom V Lee, David Sprinzak, Hamed Jafar-Nejad, Michael B Elowitz
Materialtyp: Artikel
Språk:English
Publicerad: eLife Sciences Publications Ltd 2014-09-01
Serie:eLife
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Länkar:https://elifesciences.org/articles/02950