Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts. Here, we an...
Main Authors: | Lauren LeBon, Tom V Lee, David Sprinzak, Hamed Jafar-Nejad, Michael B Elowitz |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/02950 |
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