Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models

Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models

The curative effect of single therapy for advanced cholangiocarcinoma (CCA) is poor, thus investigating combined treatment strategies holds promise for improving prognosis. Surufatinib (SUR) is a novel multikinase inhibitor that has been confirmed to prolong survival of patients with advanced CCA. P...

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Bibliographic Details
Main Authors: Yun-Peng Huang, Yong-Xiang Wang, Hui Zhou, Zhong-Tao Liu, Zi-Jian Zhang, Li Xiong, Heng Zou, Yu Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
Photodynainic therapy
Cholangicarcinoma
GPx4
ACSL4
organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1288255/full

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