Trastuzumab increases pulmonary vein arrhythmogenesis through modulating pulmonary vein electrical and conduction properties via phosphatidylinositol 3-kinase signaling

Trastuzumab increases pulmonary vein arrhythmogenesis through modulating pulmonary vein electrical and conduction properties via phosphatidylinositol 3-kinase signaling

<em><strong>Objective(s):</strong></em> Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers...

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Bibliographic Details
Main Authors: Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2020-07-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
atrial fibrillation
electrophysiology
pi3 kinase
pulmonary vein
trastuzumab
Online Access:http://ijbms.mums.ac.ir/article_15568_a1bd6a01e5c0ab9221636a483ff6da3c.pdf

Internet

http://ijbms.mums.ac.ir/article_15568_a1bd6a01e5c0ab9221636a483ff6da3c.pdf

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