CimpleG: finding simple CpG methylation signatures

Abstract DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. Here, we propose a computational framework named CimpleG for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. We show...

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Bibliographic Details
Main Authors: Tiago Maié, Marco Schmidt, Myriam Erz, Wolfgang Wagner, Ivan G. Costa
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-023-03000-0