Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells

Guanidine Derivatives Containing the Chalcone Skeleton Are Potent Antiproliferative Compounds against Human Leukemia Cells

In this study, we investigated the effects of eleven synthetic guanidines containing the 1,3-diphenylpropenone core on the viabilities of six human cancer cells. The most cytotoxic compound against human cancer cells of this series contains a <i>N</i>-tosyl group and a <i>N</i&g...

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Bibliographic Details
Main Authors: Francisco Estévez-Sarmiento, Ester Saavedra, Ignacio Brouard, Jesús Peyrac, Judith Hernández-Garcés, Celina García, José Quintana, Francisco Estévez
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
caspases
cell cycle
cytotoxicity
hybrid chalcones
guanidines
Online Access:https://www.mdpi.com/1422-0067/23/24/15518

Internet

https://www.mdpi.com/1422-0067/23/24/15518

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