Luteoloside Exerts Analgesic Effect in a Complete Freund’s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1β Expression and Macrophage/Microglia Activation

Luteoloside Exerts Analgesic Effect in a Complete Freund’s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1β Expression and Macrophage/Microglia Activation

BackgroundFlavonoid monomers are proved to have an anti-inflammatory effect and may also be promising for chronic pain treatment. In the present study, the analgesic effect and the relevant mechanisms of luteoloside, one of the flavonoid monomers, were investigated.MethodsThe analgesic effect of lut...

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Bibliographic Details
Main Authors: Chun-Yan Shi, Xi-Biao He, Chao Zhao, Hui-Jing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
analgesic effect
inflammatory pain
luteoloside
interleukin-1β
macrophage/microglia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01158/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01158/full

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