A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent's disease. Although OCRL, a direct clathrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily attributed to intracellular sorting defects. Here we show that OCRL loss...

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Bibliographic Details
Main Authors: Ramiro Nández, Daniel M Balkin, Mirko Messa, Liang Liang, Summer Paradise, Heather Czapla, Marco Y Hein, James S Duncan, Matthias Mann, Pietro De Camilli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
clathrin-mediated endocytosis
uncoating
Lowe syndrome
PI(4,5)P2
SNX9
actin comet
Online Access:https://elifesciences.org/articles/02975

Internet

https://elifesciences.org/articles/02975

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