Comprehensive and Accurate Molecular Profiling of Breast Cancer through mRNA Expression of <i>ESR1</i>, <i>PGR</i>, <i>ERBB2</i>, <i>MKI67</i>, and a Novel Proliferation Signature

Comprehensive and Accurate Molecular Profiling of Breast Cancer through mRNA Expression of <i>ESR1</i>, <i>PGR</i>, <i>ERBB2</i>, <i>MKI67</i>, and a Novel Proliferation Signature

Background: An accurate status determination of breast cancer biomarkers (ER, PR, HER2, Ki67) is crucial for guiding patient management. The “gold standard” for assessing these biomarkers in FFPE tissue is IHC, which faces challenges in standardization and exhibits substantial variability. In this s...

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Bibliographic Details
Main Authors: Anne-Sophie Wegscheider, Joanna Gorniak, Sara Rollinson, Leanne Gough, Navdeep Dhaliwal, Agustin Guardiola, Anna Gasior, Denise Helmer, Zoe Pounce, Axel Niendorf
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Diagnostics
Subjects:
APIS Breast Cancer Subtyping Kit
breast cancer
clinical performance
<i>ERBB2</i>
HER2-low
<i>ESR1</i>
Online Access:https://www.mdpi.com/2075-4418/14/3/241

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https://www.mdpi.com/2075-4418/14/3/241

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