Synthesis, evaluation, and computational chemistry of novel selenenyl sulfides as 3C protease inhibitors with strong cell-based antiviral activity

Synthesis, evaluation, and computational chemistry of novel selenenyl sulfides as 3C protease inhibitors with strong cell-based antiviral activity

The 3C protease (3Cpro) is an important enzyme for developing therapeutic medicines against some severe viral infections. In order to discover new classes of antiviral agents, 42 novel selenenyl sulfides were prepared and characterized by 1H NMR, 13C NMR, 77Se NMR and HRMS. The target compounds demo...

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Bibliographic Details
Main Authors: Jin-Yin Tang, Shengwang Dai, Xiaofang Wang, Mengting Zhang, Jin-Rui Shi, Yong-Xuan Hong, Zhi-Juan Sun, Huan-Qin Dai, Jian-Guo Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Arabian Journal of Chemistry
Subjects:
3C protease
Selenenyl sulfides
Antiviral activity
Selectivity index
Computational chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224001151

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http://www.sciencedirect.com/science/article/pii/S1878535224001151

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