Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells

Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells

Abstract Background Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mec...

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Bibliographic Details
Main Authors: Xiaoxuan Bai, Ying Wang, Xing Luo, Xiaoyi Bao, Xiuzhu Weng, Yuwu Chen, Shan Zhang, Ying Lv, Xinyu Dai, Ming Zeng, Dan Yang, Sining Hu, Ji Li, Yong Ji, Haibo Jia, Bo Yu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Cigarette tar
Atherosclerosis
Vascular smooth muscle cell
Necroptosis
Endoplasmic reticulum stress
Online Access:https://doi.org/10.1186/s12964-024-01480-6

Internet

https://doi.org/10.1186/s12964-024-01480-6

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