FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases
Osteosarcoma (OS) is an aggressive primary bone tumor which exhibits aberrantly activated Wnt signaling. The canonical Wnt signaling cascade has been shown to drive cancer progression and metastasis through the activation of β-catenin. Hence, small molecule inhibitors of Wnt targets are being explor...
| Main Authors: | , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Frontiers Media S.A.
2017-05-01
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| 丛编: | Frontiers in Pharmacology |
| 主题: | |
| 在线阅读: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00285/full |