Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo

Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo

Neutralizing antibodies (NTAbs) is a major criterion for evaluation the immunogenicity of many vaccines, for example, poliovirus and EV71 vaccine. Here, we firstly discovered that polyclonal antibodies induced by inactivated CVA16 vaccine and lived CVA16 virus have poor ability to neutralize circula...

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Bibliographic Details
Main Authors: Xin Yao, QunYing Mao, Yajing Li, Chunsheng Hao, LianLian Bian, Pan Chen, Fan Gao, Xing Wu, WeiWei Lu, Qiang Gao, XiuLing Li, Zhenglun Liang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
coxsackievirus a16
hand foot and mouth disease
neutralizing epitopes
structure
vaccine
Online Access:http://dx.doi.org/10.1080/21645515.2018.1426420

Internet

http://dx.doi.org/10.1080/21645515.2018.1426420

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