A Systematic Review on PD-1 Blockade and PD-1 Gene-Editing of CAR-T Cells for Glioma Therapy: From Deciphering to Personalized Medicine

A Systematic Review on PD-1 Blockade and PD-1 Gene-Editing of CAR-T Cells for Glioma Therapy: From Deciphering to Personalized Medicine

BackgroundProgrammed cell death protein 1 (PD-1) can attenuate chimeric antigen receptor-T (CAR-T) cell-mediated anti-tumoral immune responses. In this regard, co-administration of anti-PD-1 with CAR-T cells and PD-1 gene-editing of CAR-T cells have been suggested to disrupt this inhibitory axis. He...

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Bibliographic Details
Main Authors: Mahdi Abdoli Shadbad, Nima Hemmat, Vahid Khaze Shahgoli, Afshin Derakhshani, Farzad Baradaran, Oronzo Brunetti, Rossella Fasano, Renato Bernardini, Nicola Silvestris, Behzad Baradaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
glioma
CAR-T cells
engineered cell therapy
inhibitory immune checkpoint
single-cell sequencing
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.788211/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.788211/full

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