Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

Association of the Epithelial-to-Mesenchymal Transition (EMT) Phenotype with Responsiveness to the p21-Activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models

The p21-activated kinase (PAK) family of serine/threonine kinases, which are overexpressed in several cancer types, are critical mediators of cell survival, motility, mitosis, transcription, and translation. In the study presented here we utilized a panel of CRC cell lines to identify potential bi...

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Bibliographic Details
Main Authors: Todd M Pitts, Gillian N Kulikowski, Aik-Choon eTan, Brion William Murray, John J Arcaroli, John J Tentler, Anna eSpreafico, Heather M Selby, Maria I Kachaeva, Kelly L McPhillips, Blair C Britt, Erica Lynn Bradshaw-Pierce, Wells A Messersmith, Marileila eVarella-Garcia, S. Gail eEckhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-03-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
EMT
PF-3758309
intrinsic resistance
PAK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00035/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00035/full

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