Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy

Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy

Glutamate excitotoxicity induces neuronal cell death during epileptic seizures. Death-associated protein kinase 1 (DAPK1) expression is highly increased in the brains of epilepsy patients; however, the underlying mechanisms by which DAPK1 influences neuronal injury and its therapeutic effect on glut...

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Bibliographic Details
Main Authors: Chen-Ling Gan, Yulian Zou, Dongmei Chen, Xindong Shui, Li Hu, Ruomeng Li, Tao Zhang, Junhao Wang, Yingxue Mei, Long Wang, Mi Zhang, Yuan Tian, Xi Gu, Tae Ho Lee
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
death-associated protein kinase 1 (DAPK1)
extracellular signal-regulated kinase (ERK)
glutamate excitotoxicity
kainic acid
seizure
Online Access:https://www.mdpi.com/1422-0067/23/12/6370

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https://www.mdpi.com/1422-0067/23/12/6370

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