Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase

Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase

BackgroundAsymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered a risk factor for the pathogenesis of cardiovascular diseases. Simvastatin, a lipid‐lowering drug with other pleiotropic effects, has been widely used for treatment of car...

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Bibliographic Details
Main Authors: Chiao‐Po Hsu, Jin‐Feng Zhao, Shing‐Jong Lin, Song‐Kun Shyue, Bei‐Chia Guo, Tse‐Min Lu, Tzong‐Shyuan Lee
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
asymmetric dimethylarginine
endothelial nitric oxide synthase
NADPH oxidase
reactive oxygen species
simvastatin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.003327

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.003327

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