TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

Background: Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is loc...

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Bibliographic Details
Main Authors: Seiho Nagafuchi, Yumi Kamada-Hibio, Kanako Hirakawa, Nobutaka Tsutsu, Masae Minami, Akira Okada, Katsuya Kai, Miho Teshima, Arisa Moroishi, Yoshikazu Murakami, Yoshikazu Umeno, Yasushi Yokogawa, Kazuhiko Kogawa, Kenichi Izumi, Keizo Anzai, Ryuichi Iwakiri, Kazuyuki Hamaguchi, Nobuhiro Sasaki, Sakae Nohara, Eiko Yoshida, Mine Harada, Koichi Akashi, Toshihiko Yanase, Junko Ono, Toshimitsu Okeda, Ryoji Fujimoto, Kenji Ihara, Toshiro Hara, Yohei Kikuchi, Masanori Iwase, Takanari Kitazono, Fumiko Kojima, Suminori Kono, Hironori Kurisaki, Shiori Kondo, Hitoshi Katsuta
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
Tyrosine kinase 2 (TYK2)
Promoter variant
Diabetes mellitus
Virus
Polymorphism
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300128

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http://www.sciencedirect.com/science/article/pii/S2352396415300128

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