HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical rhythmicity and excitability in the heart and brain, but the function of HCN channels at the subcellular level in axons remains poorly understood. Here, we show that the action potential conduction velocity in both...

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Bibliographic Details
Main Authors: Niklas Byczkowicz, Abdelmoneim Eshra, Jacqueline Montanaro, Andrea Trevisiol, Johannes Hirrlinger, Maarten HP Kole, Ryuichi Shigemoto, Stefan Hallermann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
axon
HCN
conduction velocity
neuromodulation
Online Access:https://elifesciences.org/articles/42766

Internet

https://elifesciences.org/articles/42766

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