Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

Abstract Background The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxi...

Full description

Bibliographic Details
Main Authors: Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu, Yongbing Chen
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ATM
JAK1,2/STAT3
PD-L1
EMT
Cisplatin-resistant lung cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1161-8

Internet

http://link.springer.com/article/10.1186/s13046-019-1161-8

Similar Items