Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway

Abstract Background The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxi...

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Bibliographic Details
Main Authors: Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu, Yongbing Chen
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ATM
JAK1,2/STAT3
PD-L1
EMT
Cisplatin-resistant lung cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1161-8

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