In vivo Fitness of <i>Acinetobacter baumannii</i> Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections

In vivo Fitness of <i>Acinetobacter baumannii</i> Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections

We previously reported that the 14-day case fatality rate (CFR) in patients with carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) bacteremia varied between infecting clones. Here, we evaluated the in vitro and in vivo fitness of CRAB blood isolates belonging to clones with low...

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Bibliographic Details
Main Authors: Amir Nutman, Jonathan Lellouche, Ziv Lifshitz, Rivka Glick, Yehuda Carmeli
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Microorganisms
Subjects:
carbepenem-resistant <i>Acinetobacter baumannii</i> (CRAB)
fitness
in vitro growth curve assay
in vivo murine infection model
outcome
14-day mortality
Online Access:https://www.mdpi.com/2076-2607/8/6/847

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https://www.mdpi.com/2076-2607/8/6/847

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