Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

Oncolytic viruses are engineered to selectively kill tumor cells and have demonstrated promising results in early-phase clinical trials. To further modulate the innate and adaptive immune system, we generated AZD4820, a vaccinia virus engineered to express interleukin-12 (IL-12), a potent cytokine i...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Cheyne Kurokawa, Sonia Agrawal, Abhisek Mitra, Elena Galvani, Shannon Burke, Ankita Varshine, Raymond Rothstein, Kevin Schifferli, Noel R. Monks, Johann Foloppe, Nathalie Silvestre, Eric Quemeneur, Christelle Demeusoit, Patricia Kleinpeter, Puja Sapra, Carl Barrett, Scott A. Hammond, Elizabeth J. Kelly, Jason Laliberte, Nicholas M. Durham, Michael Oberst, Maria A.S. Broggi
التنسيق:	مقال
اللغة:	English
منشور في:	Elsevier 2024-03-01
سلاسل:	Molecular Therapy: Oncology
الموضوعات:	MT: Regular Issue vaccinia virus oncolytic IL-12 transgene
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2950329923000012

الانترنت

http://www.sciencedirect.com/science/article/pii/S2950329923000012

Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

الانترنت

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