Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

Abstract Background Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 tm1Rds) develop estrogen receptor-positive (ER+), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrinsic mechanisms to initiate tumorigenesis in this mo...

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Bibliographic Details
Main Authors: Hidetoshi Mori, Jane Q. Chen, Robert D. Cardiff, Zsófia Pénzváltó, Neil E. Hubbard, Louis Schuetter, Russell C. Hovey, Josephine F. Trott, Alexander D. Borowsky
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Breast Cancer Research
Subjects:
Estrogen receptor
Luminal breast cancer
Stat1-knockout mouse
Pathobiology
Tumor microenvironment
Tumor immunology
Online Access:http://link.springer.com/article/10.1186/s13058-017-0892-8

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http://link.springer.com/article/10.1186/s13058-017-0892-8

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