Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers

Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers

Introduction: Linezolid is a last-resort antibiotic for infections caused by multidrug-resistant microorganisms. It is widely used for off-label indications and for longer than recommended treatment durations, exposing patients at higher risk of adverse drug reactions (ADRs), notably thrombocytopeni...

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Main Authors: Hélène Thirot, David Fage, Antonia Leonhardt, Philippe Clevenbergh, Tatiana Besse-Hammer, Jean Cyr Yombi, Olivier Cornu, Caroline Briquet, Maya Hites, Frédérique Jacobs, Gert-Jan Wijnant, Sebastian G. Wicha, Frédéric Cotton, Paul M. Tulkens, Anne Spinewine, Françoise Van Bambeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
linezolid
thrombocytopenia
adverse drug reaction
therapeutic drug monitoring
anemia
Buzelé score
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1310309/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1310309/full

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