Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry

Identification of Degradation Products of the New Anticancer Drug Substance ONC201 by Liquid Chromatography–High-Resolution Multistage Mass Spectrometry

ONC201 (dordaviprone) is a new drug substance used in a compassionate manner to treat patients with glioblastoma. Given the clinical context and the particularly promising preclinical results, we have been asked by the medical authorities to make a first treatment available throughout France as a ho...

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Bibliographic Details
Main Authors: Maxime Annereau, Marina Vignes, Tahar Sif Eddine Bouchema, Lucas Denis, Audrey Solgadi, Victoire Vieillard, Muriel Paul, André Rieutord, Jacques Grill, Philippe-Henri Secretan, Bernard Do
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Chemosensors
Subjects:
ONC201
dordaviprone
degradation products
LC-MS<sup>2</sup>
MS fragmentation patterns
structural elucidation
Online Access:https://www.mdpi.com/2227-9040/11/5/294

Internet

https://www.mdpi.com/2227-9040/11/5/294

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