Targeting Fatty Acid-Binding Protein 4 Improves Pathologic Features of Aortic Stenosis

Targeting Fatty Acid-Binding Protein 4 Improves Pathologic Features of Aortic Stenosis

Aortic stenosis (AS) is a fibrocalcific disease of the aortic valves (AVs). Sex-differences in AS pathophysiology have recently been described. High levels of fatty acid-binding protein 4 (FAPB4) in atherosclerotic plaques have been associated with increased local inflammation, endothelial dysfuncti...

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Bibliographic Details
Main Authors: Mattie Garaikoetxea, Ernesto Martín-Núñez, Adela Navarro, Lara Matilla, Amaya Fernández-Celis, Vanessa Arrieta, Amaia García-Peña, Alicia Gainza, Virginia Álvarez, Rafael Sádaba, Eva Jover, Natalia López-Andrés
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
FABP4
aortic stenosis
sexual dimorphism
inflammation
apoptosis
calcification
Online Access:https://www.mdpi.com/1422-0067/23/15/8439

Internet

https://www.mdpi.com/1422-0067/23/15/8439

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