Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

In meiosis, DNA double-strand break (DSB) formation by Spo11 initiates recombination and enables chromosome segregation. Numerous factors are required for Spo11 activity, and couple the DSB machinery to the development of a meiosis-specific ‘axis-tethered loop’ chromosome organisation. Through in vi...

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Bibliographic Details
Main Authors: Dorota Rousová, Vaishnavi Nivsarkar, Veronika Altmannova, Vivek B Raina, Saskia K Funk, David Liedtke, Petra Janning, Franziska Müller, Heidi Reichle, Gerben Vader, John R Weir
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
meiosis
protein-protein interactions
nucleosomes
Online Access:https://elifesciences.org/articles/72330

Internet

https://elifesciences.org/articles/72330

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