Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation

Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation

Abstract Background Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development and disease, how the molecular agents collectively shape the H3K36me landscape is unclear. Results W...

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Bibliographic Details
Main Authors: Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Genome Biology
Subjects:
SETD2
NSD1
NSD2
NSD3
ASH1L
H3K36 methylation
Online Access:https://doi.org/10.1186/s13059-024-03415-3

Internet

https://doi.org/10.1186/s13059-024-03415-3

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