Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs). Here, we investigated the effect of natural enkephalinase inhibitor human op...

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Bibliographic Details
Main Authors: Pan Luo, Xuelin Li, Yuan Gao, Zhengjun Chen, Quanwei Zhang, Zhimin Wang, Xiaozhu Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
human opiorphin
inflammatory bowel diseases
ulcerative colitis
endogenous opioid system
intestinal barrier function
enkephalinase inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.904926/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.904926/full

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