Importance of Linear Combination Modeling for Quantification of Glutathione and γ-Aminobutyric Acid Levels Using Hadamard-Edited Magnetic Resonance Spectroscopy

Importance of Linear Combination Modeling for Quantification of Glutathione and γ-Aminobutyric Acid Levels Using Hadamard-Edited Magnetic Resonance Spectroscopy

BackgroundJ-difference-edited 1H-MR spectra require modeling to quantify signals of low-concentration metabolites. Two main approaches are used for this spectral modeling: simple peak fitting and linear combination modeling (LCM) with a simulated basis set. Recent consensus recommended LCM as the me...

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Bibliographic Details
Main Authors: Yulu Song, Helge J. Zöllner, Steve C. N. Hui, Kathleen Hupfeld, Georg Oeltzschner, James J. Prisciandaro, Richard Edden
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Psychiatry
Subjects:
glutathione (GSH)
γ-aminobutyric acid (GABA)
linear combination modeling
Osprey
Hadamard-edited MRS
Gaussian
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.872403/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.872403/full

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