Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Production of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-gamma-producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the regulation of memory CD8+ T cell differentiation and function during murine toxoplasmosis is...

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Bibliographic Details
Main Authors: Douglas C Wilson, Gijsbert M Grotenbreg, Kenian Liu, Yanlin Zhao, Eva-Maria Frickel, Marc-Jan Gubbels, Hidde L Ploegh, George S Yap
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2841619?pdf=render

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http://europepmc.org/articles/PMC2841619?pdf=render

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