Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety

In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous leukemia cell line that expresses the Bcr-Abl tyrosine kinase. N-(5-Nitrothiazol-...

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Bibliographic Details
Main Authors: Mehlika Dilek Altıntop, Halil Ibrahim Ciftci, Mohamed O. Radwan, Belgin Sever, Zafer Asım Kaplancıklı, Taha F. S. Ali, Ryoko Koga, Mikako Fujita, Masami Otsuka, Ahmet Özdemir
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
thiadiazole
thiazole
benzothiazole
Bcr-Abl
kinase inhibitor
leukemia
Online Access:https://www.mdpi.com/1420-3049/23/1/59

Internet

https://www.mdpi.com/1420-3049/23/1/59

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