Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5

Human T-cell leukemia virus type 1 (HTLV-1) encodes a protein derived from the antisense strand of the proviral genome designated HBZ (HTLV-1 basic leucine zipper factor). HBZ is the only viral gene consistently expressed in infected patients and adult T-cell leukemia/lymphoma (ATL) tumor cell lines...

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Bibliographic Details
Main Authors: Amanda R. Panfil, Jacob Al-Saleem, Cory M. Howard, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Patrick L. Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Microbiology
Subjects:
HTLV-1
HBZ
UBR5
ubiquitin
proliferation
T-cell
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00080/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00080/full

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