Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway

Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway

Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this resear...

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Bibliographic Details
Main Authors: Ke Liu, Lulu Li, Zhijun Liu, Gang Li, Yanqing Wu, Xingjun Jiang, Mengdie Wang, Yanmin Chang, Tingting Jiang, Jianheng Luo, Jiahui Zhu, Hongge Li, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischemia-reperfusion injury
metformin
AMP-activated protein kinase
neuronal apoptosis
brain-derived neurotrophic factor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.832611/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.832611/full

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