Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration

Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration

JustificationWe have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Lactococcus lactis W136, a probiotic bacterium, improves sinus-specific symptoms, SNOT-22, and mucosal aspect on endoscopy, accompanied by a reductio...

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Bibliographic Details
Main Authors: Saud Al-Romaih, Oumkaltoum Harati, Leandra Endam Mfuna, Ali Filali-Mouhim, Audrey Pelletier, Axel Renteria Flores, Martin Desrosiers
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Allergy
Subjects:
chronic rhinosinusitis (CRS)
nasal polyposis
probiotics
microbiome
transriptomic
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2023.1046684/full

Internet

https://www.frontiersin.org/articles/10.3389/falgy.2023.1046684/full

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