Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease

Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease

A series of new imidazole-phenazine derivatives were synthesized via a two-step process. The condensation of 2,3-diaminophenazine and benzaldehyde derivatives proceeds with intermediate formation of an aniline Schiff base, which undergoes subsequent cyclodehydrogenation in situ. The structures of th...

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Bibliographic Details
Main Authors: Nur Sarah Dyana Khalili, Muhammad Hidhir Khawory, Nurul Hanim Salin, Iffah Izzati Zakaria, Maywan Hariono, Andrey A. Mikhaylov, Ezatul Ezleen Kamarulzaman, Habibah A Wahab, Unang Supratman, Mohamad Nurul Azmi
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Imidazole phenazines
Anti-dengue
DENV2 NS2B-NS3 protease
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024002330

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http://www.sciencedirect.com/science/article/pii/S2405844024002330

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