Overexpression of REST Represses the Epithelial–Mesenchymal Transition Process and Decreases the Aggressiveness of Prostate Cancer Cells

Overexpression of REST Represses the Epithelial–Mesenchymal Transition Process and Decreases the Aggressiveness of Prostate Cancer Cells

The RE-1 silencing transcription factor (REST) is a repressor factor related to neuroendocrine prostate cancer (PCa) (NEPC), a poor prognostic stage mainly associated with castration-resistant PCa (CRPC). NEPC is associated with cell transdifferentiation and the epithelial–mesenchymal transition (EM...

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Bibliographic Details
Main Authors: Sebastián Indo, Octavio Orellana-Serradell, María José Torres, Enrique A. Castellón, Héctor R. Contreras
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer (PCa)
RE-1 silencing transcription factor (REST)
neuroendocrine PCa (NEPC)
epithelial–mesenchymal transition (EMT)
Online Access:https://www.mdpi.com/1422-0067/25/6/3332

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https://www.mdpi.com/1422-0067/25/6/3332

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