Lactate Dehydrogenase-B Oxidation and Inhibition by Singlet Oxygen and Hypochlorous Acid

Alterations in cellular energy metabolism are a hallmark of cancer and lactate dehydrogenase (LDH) enzymes are overexpressed in many cancers regardless of sufficient oxygen and functional mitochondria. Further, L-lactate plays signaling roles in multiple cell types. We evaluated the effect of single...

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Bibliographic Details
Main Authors: Lisa M. Landino, Emily E. Lessard
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Oxygen
Subjects:
Online Access:https://www.mdpi.com/2673-9801/4/4/27