Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol

Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol

Objective: Low-density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are opposing regulators of plasma LDL-cholesterol levels. The PCSK9 gene exhibits many single or compound polymorphisms within or among mammalian species. This is case between the SPRET/EiJ (...

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Bibliographic Details
Main Authors: Francine Sirois, Michel Chrétien, Majambu Mbikay
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Mus spretus
PCSK9
Genetic variation
LDLR
Lipoprotein
Cholesterol
Promoter
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426916301070

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http://www.sciencedirect.com/science/article/pii/S2214426916301070

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